First-in-human Phase I trial of BI 836880, a vascular endothelial growth factor/angiopoietin-2-blocking Nanobody®, given every 3 weeks in patients with advanced/metastatic solid tumors
Christophe Le Tourneau, Rainer Claus, Francesco Ricci, Björn Hackanson, Christoph Rummelt, Oliver Fietz, Thomas Arnhold, Dooti Roy, Zohra Oum’Hamed, Ralph Fritsch
In the European Union, afatinib is approved for use in TKI-naive adults with locally advanced or metastatic NSCLC with activating EGFR mutations and in patients with NSCLC of squamous histology on or after chemotherapy. It is not yet approved in other indications.
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