Impact of afatinib dosing on safety and effectiveness in patients with EGFR mutation-positive advanced NSCLC in a real-world setting (RealGiDo)
Balazs Halmos, Eng-Huat Tan, Ross Soo, Jacques Cadranel, Min Ki Lee, Pascal Foucher, Te-Chun Hsia, Maximilian Hochmair, Frank Griesinger, Toyoaki Hida, Edward S. Kim, Barbara Melosky, Angela Märten, Enric Carcereny
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In the European Union, afatinib is approved for use in TKI-naive adults with locally advanced or metastatic NSCLC with activating EGFR mutations and in patients with NSCLC of squamous histology on or after chemotherapy. It is not yet approved in other indications.
In Australia GIOTRIF is indicated as monotherapy for the treatment of patients with advanced or metastatic non-squamous non-small cell carcinoma of the lung, either as first line therapy or after failure of cytotoxic chemotherapy. Tumours must have Epidermal Growth Factor Receptor (EGFR) exon 19 deletions or L858R substitution mutations.
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