ELCC 2018 - Pavlakis presentation

ELCC 2018 - Pavlakis presentation

Nintedanib + pemetrexed/cisplatin in malignant pleural mesothelioma: Phase II biomarker data from the LUME-Meso study

Pavlakis N, Grosso F, Steele N, Nowak A, Novello S, Popat S, Greillier L, Reck, M, Kitzing T, Scagliotti G

Related articles

Learn more about the science behind this presentation in the papers and other materials below.


Nintedanib plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma: Phase II results from the randomized, placebo-controlled LUME-Meso trial
Grosso F et al. JCO 2017; DOI: 10.1200/JCO.2017.72.9012
LUME-Meso: design and rationale of the Phase III part of a placebo-controlled study of nintedanib and pemetrexed/cisplatin followed by maintenance nintedanib in patients with unresectable malignant pleural mesothelioma
Scagliotti G et al. CLC 2017; DOI: 10.1016/j.cllc.2017.03.010

Nintedanib is being investigated in malignant pleural mesothelioma (MPM) and is not approved for this use. The efficacy and safety of nintedanib in MPM have not been established.


Nintedanib is approved in the EU under the brand name VARGATEF® for use in combination with docetaxel in adult patients with locally advanced, metastatic or locally recurrent NSCLC of adenocarcinoma tumour histology after first-line chemotherapy. For the full list of country-specific information please click here. Nintedanib is not approved in other oncology indications.


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Last updated: April 2018