IMIG 2018 – Popat et al. poster

IMIG 2018 – Popat et al. poster

Phase II LUME-Meso study of first-line nintedanib plus chemotherapy in malignant pleural mesothelioma: additional efficacy analyses

Popat S, Novello S, Nowak A, Grosso F, Steele N, Greillier L, John T, Leighl NB, Reck M, Pavlakis N, Sørensen JB, Planchard D, Ceresoli GL, Hughes B, Mazières J, Socinski MA, von Wangenheim U, Barrueco J, Morsli N and Scagliotti G

This poster is presented for scientific education and its content may go beyond the scope of the current market authorization for nintedanib in Canada.

Related articles

Learn more about the science behind this presentation in the papers and other materials below


Nintedanib plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma: Phase II results from the randomized, placebo-controlled LUME-Meso trial

Grosso F et al. JCO 2017; DOI: 10.1200/JCO.2017.72.9012

LUME-Meso: design and rationale of the Phase III part of a placebo-controlled study of nintedanib and pemetrexed/cisplatin followed by maintenance nintedanib in patients with unresectable malignant pleural mesothelioma

Scagliotti G et al. CLC 2017; DOI: 10.1016/j.cllc.2017.03.010

Nintedanib is being investigated in malignant pleural mesothelioma (MPM) and is not approved for this use. The efficacy and safety of nintedanib in MPM have not been established.


Nintedanib is approved in the EU under the brand name VARGATEF® for use in combination with docetaxel in adult patients with locally advanced, metastatic or locally recurrent NSCLC of adenocarcinoma tumour histology after first-line chemotherapy. For the full list of country-specific information please click here. Nintedanib is not approved in other oncology indications.


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Last updated: May 2018