Competing CNS or systemic progression analysis for EGFR mutation-positive NSCLC patients on afatinib in LUX-Lung 3, 6, and 7

Diego Kaen, James C.-H. Yang, Yi-Long Wu, Vera Hirsh, Kenneth O’Byrne, Nobuyuki Yamamoto, Sanjay Popat, Akihiro Tamiya, Angela Märten, Martin Schuler

LALCA CNS activity poster

Related Materials

Learn more about the science behind this poster in the videos, papers and other materials below.

First-Line Afatinib versus Chemotherapy in Patients with Non-Small Cell Lung Cancer and Common Epidermal Growth Factor Receptor Gene Mutations and Brain Metastases.

Schuler M et al. J Thorac Oncol. 2016;11(3):380-90.

Watch Vera Hirsh's opinion on the treatment of brain metastases!

Vera Hirsh

Optimizing outcomes in EGFR mutation-positive NSCLC: which tyrosine kinase inhibitor and when?

Girard N. Future Oncol. 2018;14(11):1117–1132.

Afatinib versus gefitinib in patients with EGFR mutation-positive advanced non-small-cell lung cancer: overall survival data from the phase IIb LUX-Lung 7 trial

Paz-Ares L, et al. Ann Oncol. 2017;28(2):270–277.

Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials

Yang JC, et al. Lancet Oncol. 2015;16(2):141–151.


In the European Union, afatinib is approved for use in TKI-naive adults with locally advanced or metastatic NSCLC with activating EGFR mutations and in patients with NSCLC of squamous histology on or after chemotherapy. It is not yet approved in other indications.

In Switzerland, Afatinib is approved as monotherapy for patients with non-small cell lung cancer (NSCLC, stage IIIb/IV) with activating mutations of EGFR (exon 19 deletions or exon 21 L858R substitutions), not previously treated with EGFR TKIs. It is also indicated for the treatment of patients with locally advanced or metastatic squamous cell cancer of the lung whose carcinoma progressed during or after platinum-based chemotherapy and for whom immunotherapy is not suitable.