Following the introduction of immune checkpoint inhibitors (ICIs), more treatment options are becoming available in non-small cell lung cancer (NSCLC), and many patients are now treated with first- or second-line ICIs. Consequently, it is becoming increasingly important in clinical practice to establish the optimal treatment after failure on ICI therapy (with or without chemotherapy).1
In the post-(chemo-) immunotherapy setting, there is a lack of high-quality evidence from prospective clinical trials to optimize later-line treatment selection.1 Anti-angiogenic modulation may facilitate normalization of tumor vasculature and promote a more immune-supportive environment.1 Thus, treatment with an anti-angiogenic plus docetaxel may be an option in patients who progress after chemotherapy and ICI therapy.1
Preliminary data from two published datasets suggest that patients who progress on previous chemotherapy and ICI therapy may benefit from treatment with nintedanib* plus docetaxel.2,3
Nintedanib plus docetaxel after chemotherapy and ICI therapy in the Spanish compassionate use study2
In this retrospective analysis of patients in Spain who participated in the nintedanib compassionate use study, 11 patients received nintedanib plus docetaxel after chemotherapy and ICI therapy (nivolumab, n=3; pembrolizumab, n=4; atezolizumab, n=4).2
Treatment with nintedanib plus docetaxel was associated with:
OS from the start of treatment with nintedanib plus docetaxel (n=11)
CI, confidence interval; OS, overall survival.
VARGADO Cohort B: nintedanib plus docetaxel after first-line chemotherapy and second-line ICI therapy
VARGADO is a prospective, non-interventional study of nintedanib plus docetaxel after first-line chemotherapy in the routine clinical treatment of patients with locally advanced, metastatic or locally recurrent adenocarcinoma NSCLC.3
In a recent interim analysis of Cohort B, 57 patients had received nintedanib plus docetaxel after first-line chemotherapy and second-line treatment with ICIs.3 At the time of the interim analysis (data cut-off: 2 December 2019), median duration of follow-up was 6.6 months.3 Median PFS was 6.5 months (95% confidence interval [CI]: 4.8–8.7; n=47) and median OS was 12.4 months (CI: 11.4–14.1; n=55). ORR was 50% (n=20/40) and DCR was 85% (n=34/40).3
The most common Grade ≥3 nintedanib-related adverse events were decreased white blood cell count (9%), stomatitis (5%), and diarrhea or nausea (both 2%).3
OS from the start of third-line nintedanib plus docetaxel after failure of ICI therapy (n=55)
CI, confidence interval; ICI, immune checkpoint inhibitor; OS, overall survival.
PFS from the start of third-line nintedanib plus docetaxel after failure of ICI therapy (n=47)
CI, confidence interval; ICI, immune checkpoint inhibitor; PFS, progression-free survival.
Popat S, et al. Lung Cancer 2020;144:76–84.
Corral, J et al. Clin Transl Oncol 2019;21(9):1270–79.
Grohé C, et al. Poster presented at ASCO20 Virtual 2020 (Poster 370).
*Nintedanib is approved in the EU under the brand name VARGATEF® for use in combination with docetaxel in adult patients with locally advanced, metastatic or locally recurrent NSCLC of adenocarcinoma tumor histology after first-line chemotherapy. For the full list of country-specific information, please click here. Nintedanib is not approved in other oncology indications.
© 2020 Boehringer Ingelheim International GmbH. All rights reserved.
Page last updated: August 2020
Some links in this area will let you leave Boehringer Ingelheim's site and visit external websites. If not indicated otherwise in the imprint of the external website, the linked sites are not under the control of the Boehringer Ingelheim corporation and no entity of the Boehringer Ingelheim group of companies is responsible for the contents of such linked site or any link contained in such linked site, or any changes or updates to such sites. Neither is any entity of the Boehringer Ingelheim group of companies responsible for webcasting or any other form of transmission received from any linked site. These links are provided to you only as a convenience, and the inclusion of any link does not imply endorsement by the Boehringer Ingelheim group of companies of the site. In particular, Boehringer Ingelheim is not in a position to monitor the linked third party websites completely and permanently for violations of the law. Boehringer Ingelheim therefore accepts no responsibility for the accuracy or any other aspect of the information on this website. Boehringer Ingelheim is liable, if at all, only to the extent that it was aware of illegal content and it was technically possible and reasonable to prevent its use. The data protection declaration for this website does not apply to such linked websites.
Do you want to continue ?Continue