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Retrospective Study of Sequential Therapy with Afatinib Followed by Osimertinib in EGFR Mutation-Positive NSCLC
A non-interventional chart review based on existing medical records of patients with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer (NSCLC) who were treated with first-line afatinib*, developed the T790M mutation and were then treated with second-line osimertinib.
Trial CT.gov-Identifier: NCT03370770
EGFR mutation-positive advanced NSCLC
Common EGFR mutations (del19, L858R) at start of first-line treatment with afatinib
Initiation of second-line osimertinib treatment for acquired T790M mutation at least 10 months prior to data entry
Primary outcome measure:
Secondary outcome measure:
Clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT03370770 (Accessed: May 2018).
*Afatinib is approved in more than 80 markets including the EU, Japan, Taiwan, and Canada under the brand name GIOTRIF®, in the US under the brand name GILOTRIF® and in India under the brand name Xovoltib®; for the full list please see here. Registration conditions differ internationally; please refer to locally approved prescribing information.
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Last updated: June 2018
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