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Afatinib in Combination with Pembrolizumab in Patients with Stage IIIB/IV Squamous Cell Carcinoma of the Lung
A Phase II, open-label, single-arm trial of afatinib* in combination with pembrolizumab in patients with locally advanced or metastatic squamous cell lung carcinoma (SqCC) who have progressed during or after first-line, platinum-based chemotherapy.
Trial CT.gov-Identifier: NCT03157089
QD, once daily; Q3W, every 3 weeks; RP2D, recommended Phase II dose
Primary outcome measure:
Secondary outcome measures:
The safety run-in is ongoing in the USA, Spain, France, Turkey and South Korea.
Clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT03157089 (Accessed: March 2018).
Levy B, et al. Poster presented at ASCO 2018 (Poster TPS9117).
*Afatinib is approved in more than 80 markets including the EU, Japan, Taiwan, and Canada under the brand name GIOTRIF®, in the US under the brand name GILOTRIF® and in India under the brand name Xovoltib®; for the full list please see here. Registration conditions differ internationally; please refer to locally approved prescribing information.
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Last updated: June 2018
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