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The 2017 American Society of Clinical Oncology (ASCO) Annual Meeting took place on 2–6 June 2017 at McCormick Place convention centre, Chicago, Illinois.
Boehringer Ingelheim presented overall survival analysis of the LUME-Meso trial, results of the Phase III LUX-Head and Neck 2 trial and results of the first-in-man Phase I trial of the novel BET inhibitor, BI894999*.
For more details, please see below.
The full ASCO 2017 programme can be found here.
Phase I first-in-man trial of a novel bromodomain and extra-terminal domain (BET) inhibitor (BI 894999) in patients (Pts) with advanced solid tumors. (Abstract 2504)
LUX-head and neck 2: Randomized, double-blind, placebo-controlled, phase III trial of afatinib** as adjuvant therapy after chemoradiation (CRT) in primary unresected, high/intermediate-risk, squamous cell cancer of the head and neck (HNSCC) patients (pts). (Abstract 6001)
Mature overall survival (OS) results from the LUME-Meso study of nintedanib¶ (N) + pemetrexed/cisplatin (PEM/CIS) vs placebo (P) + PEM/CIS in chemo-naïve patients (pts) with malignant pleural mesothelioma (MPM) (Abstract 8506)
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*This is an investigational compound and has not been approved. Its safety and efficacy have not been established.
**Afatinib is approved in more than 70 markets including the EU, Japan, Taiwan, and Canada under the brand name GIOTRIF®, in the US under the brand name GILOTRIF® and in India under the brand name Xovoltib®; for the full list please see here. Registration conditions differ internationally; please refer to locally approved prescribing information.
¶Nintedanib is approved in the EU under the brand name VARGATEF® for use in combination with docetaxel in adult patients with locally advanced, metastatic or locally recurrent NSCLC of adenocarcinoma tumour histology after first-line chemotherapy. For the full list of country-specific information please click here. Nintedanib is not approved in other oncology indications.
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