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Long-term treatment: LUX-Lung 3, 6, 7 and 8
In the LUX-Lung 3, LUX-Lung 6 and LUX-Lung 7 studies, 10–12% of afatinib-treated* patients were long-term responders (LTRs; treated for ≥3 years).1 In LUX-Lung 7, 12% of afatinib-treated patients versus 4% of gefitinib patients were LTRs. Long-term treatment was independent of tolerability-guided dose adjustment and of the presence of brain metastases at time of enrolment. Long-term treatment with afatinib had no detrimental impact on subsequent treatment.1
Patients treated for at least 2, 2.5 and 3 years in the overall LUX-Lung 3, 6 and 7 populations1,2
Note: For LUX-Lung 7, percentages are based on total number of patients who received treatment with afatinib or gefitinib
In LUX-Lung 8, 21 out of 398 patients in the afatinib arm were long-term responders who had received at least 12 months of afatinib treatment.3 Median treatment duration in these patients was 17.6 months (range 12.3–27.6 months). Median progression-free survival (PFS) was 16.6 months (range 2.8–25.8) and median overall survival (OS) was 21.1 months (range 12.9–31.6); one patient had a complete response and six patients had a partial response.3
Schuler M, et al. Eur J Cancer 2017;72(Suppl. 1):S176-S7.
Yang JC-H, et al. Presented at the 2017 Japanese Society of Medical Oncology Annual Meeting (Abstract 70046).
Gadgeel SM, et al. Eur J Cancer 2017;72(Suppl. 1):S185.
*Afatinib is approved in more than 80 markets, including the EU, Japan, Taiwan and Canada under the brand name GIOTRIF®, in the US under the brand name GILOTRIF® and in India under the brand name Xovoltib®; for the full list, please click here. Registration conditions differ internationally; please refer to locally approved prescribing information.
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Last updated: October 2018
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